Erythrodermic psoriasis improved by panitumumab, but not bevacizumab.
نویسندگان
چکیده
Psoriasis is considered to be a disease mediated by Th17/ Th1 immunity, with the production of interleukin (IL)17, IL-22, and interferon (IFN)-γ. Previous evidence has also demonstrated the possible involvement of epidermal growth factor receptor (EGFR) ligands and vascular endothelial growth factor (VEGF) (1–5). Panitumumab is a human monoclonal antibody targeting EGFR. On the other hand, bevacizumab is a humanized monoclonal antibody that binds VEGF. Here, we observed clinical effects of these antibodies administered for rectal cancer in a patient with psoriasis.
منابع مشابه
Erythrodermic Psoriasis in a Man with Monoclonal B-cell Lymphocytosis
Erythroderma is characterized by erythema involving greater than 90% of the body surface area and may be caused by several etiologies, including erythrodermic psoriasis. Psoriasis is an autoimmune skin and systemic condition characterized by erythematous and scaly plaques. Monoclonal B-cell lymphocytosis is an asymptomatic hematological disorder diagnosed by elevated, small, clonal B-cell count...
متن کاملErythrodermic Psoriasis Treated with Golimumab: A Case Report
Erythrodermic psoriasis (EP) is a very severe variant of psoriasis whose management poses a challenge to physicians, as currently available therapies often provide unsatisfactory results. Many biologics have been used to treat chronic plaque psoriasis, the most common form of psoriasis; however, their effectiveness for EP is poorly understood. A recently developed biologic, golimumab, has been ...
متن کاملA randomized Phase II clinical study of combining panitumumab and bevacizumab, plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) compared with FOLFIRI alone as second-line treatment for patients with metastatic colorectal cancer and KRAS mutation
BACKGROUND This study investigated the efficacy and safety of a new treatment strategy of combining panitumumab and bevacizumab, plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) versus FOLFIRI alone as second-line chemotherapy for metastatic colorectal cancer (mCRC) patients with known V-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS) mutation status. METHODS Patients with mCRC who...
متن کاملA severe case of erythrodermic psoriasis associated with advanced nail and joint manifestations: a case report
INTRODUCTION Erythrodermic psoriasis is a rare generalized clinical presentation of psoriasis in children and adults. Its systemic involvement and a diverse range of clinical findings in the joint and nails are commonly described. A high index of suspicion and an exhaustive differential diagnosis involving other causes of erythroderma should be initially considered. CASE PRESENTATION We prese...
متن کاملErythrodermic psoriasis with bullous pemphigoid: combination treatment with methotrexate and compound glycyrrhizin
UNLABELLED We report a case of erythrodermic psoriasis with bullous pemphigoid (BP) in a 68-year-old male. The patient had a history of psoriasis for 35 years and tense, blisterlike lesions for 4 months. He presented with diffuse flushing, infiltrative swelling, and tense blisterlike lesions on his head, trunk, and limbs. This patient was successfully treated by a combination of methotrexate an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta dermato-venereologica
دوره 92 4 شماره
صفحات -
تاریخ انتشار 2012